How much allopurinol is lethal?
Massive overdosing or acute poisoning by ZYLOPRIM (allopurinol) has not been reported. In mice, the 50% lethal dose (LD50) is 160 mg/kg given intraperitoneally (IP) with deaths delayed up to 5 days and 700 mg/kg orally (PO) (approximately 140 times the usual human dose) with deaths delayed up to 3 days.
Can allopurinol cause death?
They found an IR of 0.69 per 1000 person-years in allopurinol recipients versus 0.04 in nonusers. Twelve deaths occurred in the 45 patients with allopurinol-induced SCARs (26.7%) versus 1 death in the 10 patients with SCARs unrelated to allopurinol.
How much is too much allopurinol?
The maximum recommended dose is 800 mg. Doses higher than 300 mg should be divided into two or three smaller doses per day.
Does allopurinol shorten your life?
Results: Long term low dose allopurinol was associated with a significant worsening in mortality over those who never received allopurinol (relative risk 2.04, 95% confidence interval (CI) 1.48 to 2.81). This may be because low dose allopurinol is insufficient to negate the adverse effect of a high urate concentration.
Does allopurinol damage the liver?
Allopurinol is a rare but well known cause of acute liver injury that has features of a hypersensitivity reaction and can be severe and even fatal.
What happens if I stop taking allopurinol?
What will happen if I stop taking it? If you stop allopurinol treatment suddenly, there is a high risk that gout may get worse or you will get serious side effects. Only stop taking allopurinol if a doctor tells you to. A doctor will help you to reduce your dose slowly so you do not get serious side effects.
Is there an alternative to allopurinol?
Febuxostat, a novel nonpurine selective inhibitor of xanthine oxidase, is a potential alternative to allopurinol for patients with hyperuricemia and gout.
What are the side effects of allopurinol?
Side Effects Stomach upset, nausea, diarrhea, or drowsiness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Do I have to take allopurinol forever?
Treatment with allopurinol is usually long-term unless you experience an adverse effect. Continue to take the tablets unless you are advised otherwise by a doctor. There are a number of lifestyle changes that you can make to help reduce the risk of having a gout attack.
Is allopurinol bad for your heart?
Yet another study of gout patients using Scottish database reported that compared to non-use, allopurinol use was associated with higher (not lower) adjusted hazards of cardiovascular hospitalization (including coronary artery disease (CAD), hypertensive heart disease, heart failure, stroke, other cardiovascular …
Who should not take allopurinol?
chronic heart failure. liver problems. moderate to severe kidney impairment. HLA-B *58:01 positive.
What are the side effects of allopurinol 300 mg?
Stomach upset, nausea, diarrhea, or drowsiness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects.
How many milligrams of allopurinol should I take?
Usually you’ll start with between 100 mg and 300 mg daily but your doctor will take regular blood tests and may increase the dose (up to 900 mg daily) if your urate level isn’t coming down far enough for the urate crystals to dissolve.
Is it safe to breast feed while taking allopurinol?
It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk. How should I take allopurinol? Take allopurinol exactly as prescribed by your doctor.
Can you take febuxostat while taking allopurinol?
If you do have an acute attack of gout while on allopurinol, don’t stop taking it. If you’re unable to continue taking allopurinol because of your side effects, you may be able to take febuxostat instead, which works in a similar way to allopurinol.
What does a 300 mg allopurinol Pill look like?
Drug: Allopurinol; Strength: 300 mg; Pill Imprint: 0524 0410; Color: Orange; Shape: Round
How many mg of allopurinol can you take in one day?
-Average maintenance dose: 400 to 600 mg orally/day in divided doses. Minimal Effective Dose: 100 to 200 mg per day. Maximum Dose: 800 mg per day. Comments: -Oral doses in excess of 300 mg/day should be given in divided doses, preferably after meals to minimize gastric irritation.
Who is at risk for kidney damage from allopurinol?
The dosage of allopurinol needs reducing in people with kidney disease and their renal function monitored at least during the early stages of therapy. People administered allopurinol for high uric acid levels occurring as a result of cancer are at higher risk of developing kidney damage from allopurinol.
How is allopurinol used in the treatment of gout?
Allopurinol is used to treat gout or kidney stones. Allopurinol is also used to decrease levels of uric acid in people who are receiving cancer treatment.