How long does it take for Lysodren to work?

This medication should take effect within 1 to 2 days; however, effects are not always visibly obvious and therefore laboratory tests may be needed to evaluate this medication’s effectiveness.

What’s the best treatment for Cushing’s disease in dogs?

Veterinarians have often used a human chemotherapy drug, Lysodren (mitotane), “off-label” to treat Cushing’s in dogs. Lysodren destroys the layers of the adrenal gland that produce cortisol.

How often should I give my Dog Lysodren?

Once regulated, your dog will take Lysodren® approximately once weekly, but your veterinarian will determine the best dosing schedule for your dog. An ACTH stimulation test will be necessary about every 3-4 months to be sure that regulation is satisfactory.

How long does it take for Cushing’s disease to stop?

Treatment with mitotane (brand name Lysodren®) involves an initiating phase and a maintenance phase. The initiating phase arrests the disease and restores the dog to a more normal state. Some of the clinical signs, especially increased food and water intake, should stop within the first 1-3 weeks.

How is mitotane used to treat Cushing’s disease?

Learn more about our COVID-19 response and guidelines. Treatment with mitotane (brand name Lysodren®) involves an initiating phase and a maintenance phase. The initiating phase arrests the disease and restores the dog to a more normal state.

Veterinarians have often used a human chemotherapy drug, Lysodren (mitotane), “off-label” to treat Cushing’s in dogs. Lysodren destroys the layers of the adrenal gland that produce cortisol.