Mechanism of Action Phenobarbital is known to induce the liver’s cytochrome p450 enzyme. The induction of this enzyme speeds up the metabolism of estrogens and progestins.
What is the onset of action of phenobarbital?
Long-acting phenobarbital has onset of action of 1 hour or longer and duration of actions of 10 to 12 hours.
How do I know if my dog is taking too much phenobarbital?
Symptoms of over dosage of Phenobarbital are ataxia (drunk acting), lethargy, sedation, recumbency (inability to stand), depression, hypothermia (decreased temperature), coma, and death.
Why is my dog still having seizures while on phenobarbital?
While the majority of dogs respond very well to Phenobarbital and/or potassium bromide, there are a few dogs that will continue to have a high seizure frequency despite having adequate serum levels of these medications, and are called “refractory”. For these dogs newer anticonvulsants may help.
Can you give a dog too much phenobarbital?
Dosage of Phenobarbital for dogs Missing a dose can result in your dog having seizures. Overdose can cause depression in the nervous system. Therefore it is essential to give Phenobarbital to your dog as prescribed and instructed by your vet.
What happens when you take phenobarbital?
Dizziness, drowsiness, excitation, headache, tiredness, loss of appetite, nausea, or vomiting may occur as your body adjusts to the medication. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.
What should I do if I miss a dose of phenobarbital?
Store at room temperature away from moisture, heat, and light. Keep track of the amount of medicine used from each new bottle. Phenobarbital is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription. What happens if I miss a dose? Take the missed dose as soon as you remember.
How long has my Dog been on phenobarbital?
After the second seizure, the vet put him on phenobarbital (97 mg/2x per day). He’s been on it for five days now and is still pretty out of it. He is extremely lethargic (sleeps most of the day), has coordination problems, and weakness in his hind end.
When did they put Jake on phenobarbital Keppra?
My jake is 18 months old and started having seizures in March. He didn’t have another until two months later. The vet put him on keppra and two weeks later he had a seizure on Saturday and another on Sunday. The vet then put him on phenobarbital and increased his keppra to taking two twice a day.
How is phenobarbital used in the treatment of seizures?
Phenobarbital slows the activity of your brain and nervous system. Phenobarbital is used to treat or prevent seizures. Phenobarbital is also used short-term as a sedative to help you relax. Phenobarbital may also be used for purposes not listed in this medication guide.
How often should you test your dog for phenobarbital?
Your veterinarian will likely want to take blood tests frequently, about every 2-6 months, to monitor your dog’s liver function, as phenobarbital can negatively affect it over long periods of time.
My jake is 18 months old and started having seizures in March. He didn’t have another until two months later. The vet put him on keppra and two weeks later he had a seizure on Saturday and another on Sunday. The vet then put him on phenobarbital and increased his keppra to taking two twice a day.
What does a Lab look like before a seizure?
Before the seizure, your lab may look dazed and confused. Some dogs try to find closed places and behave unsteadily. Some dogs start looking at the ceiling.
Why did my dog have an allergic reaction to phenobarbital?
With those points out of the way, let’s get back to the article. TL;DR – if your dog is recently on phenobarbital and has symptoms such as a suppressed white blood cell count and autoimmune issues (something that looks like an allergic reaction) then phenobarbital may be the cause.
